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An infant’s eyes turn bright blue temporary after taking Covid-19 medication

In Thailand, a 6-month-old baby’s dark brown eyes turned bright blue temporarily after receiving the Covid-19 treatment Favipiravir, approved for children with mild to moderate symptoms.

Similar cases have been reported, raising questions about the medication’s side effects.

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THAILAND: A 6-month-old Thai baby’s eyes underwent a temporary colour change from dark brown to bright blue after receiving oral treatment for Covid-19, Favipiravir, which is approved by the Thai Ministry of Public Health.

The 6-month-old from Thailand was diagnosed with Covid-19 after suffering from a fever and a cough for a day, as detailed in a case published in the medical journal Frontiers in Pediatrics.

Favipiravir is an antiviral treatment approved by the Thai Ministry of Public Health in 2022 for children with mild to moderate symptoms.

Approximately 18 hours after commencing the medication, the child’s mother observed a startling transformation in her son’s eye colour from dark brown to blue hue.

She promptly contacted medical professionals who advised her to discontinue the treatment immediately.

After roughly five days, the discolouration gradually faded, and the child’s cornea returned to its original colour.

Thereafter, doctors conducted a thorough examination and found the cornea had cleared and lacked a bluish hue. At the same time, no blue pigment deposit was noted on the surface of the iris or the anterior lens capsule.

While experts remain uncertain about the exact cause of Favipiravir-induced discolouration, they speculate that it may be linked to fluorescence, the emission of absorbed light, possibly originating from the drug, its metabolites, or additional tablet components like titanium dioxide and yellow ferric oxide.

Prior research has indicated a direct relationship between the concentration of Favipiravir and fluorescence intensity, particularly in human hair and nails.

Fortunately, the child did not experience any vision impairment and successfully recovered from their Covid-19 symptoms.

Common side effects of Favipiravir include mild hyperuricemia (elevated uric acid levels), diarrhoea, and neutropenia (reduced white blood cell neutrophils), constituting approximately 20% of adverse reactions. However, the drug has caused corneal discolouration in one previously documented case.

In 2021, a man in India reported the first case of the unusual adverse effect of the treatment.

A 20-year-old man in India reported the first case of the unusual adverse effect of the treatment in 2021

According to the New York Post, an unnamed 20-year-old was diagnosed with Covid-19 and prescribed Favipiravir after two days of seeing no improvements while taking vitamin C, zinc, vitamin A, vitamin D, and ivermectin.

But on his second day of Favipiravir treatment, the man noticed that his dark brown eyes had become bright blue. Doctors advised the man to stop taking the medication, and his eyes returned to their normal color after just one day.

The report about the infant was published in April 2023, but the exact date of the incident is unknown.

Favipiravir is approved in Japan, Russia, Ukraine, Uzbekistan, Moldova, and Kazakhstan and received approval for emergency use in Italy in 2020.

Favipiravir is approved as a Covid-19 treatment in several countries. Kimimasa Mayama/EPA

Researchers in the United States consider the medication an effective therapy for Covid-19, after several studies have tested the efficacy of the drug’s ability to combat the disease, but it has not been approved by the US Food and Drug Administration.

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Singapore to offer Mpox vaccine to high-risk healthcare workers and close contacts

Singapore will offer free mpox vaccines to high-risk healthcare workers and close contacts of confirmed cases, amid concerns over the deadlier clade 1 strain. The Ministry of Health stated mask-wearing is unnecessary for the public, as the virus primarily spreads through close contact.

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Singapore has announced new measures to combat the spread of the deadlier mpox clade 1 strain, as concerns mount over its potential impact.

At a press conference on Wednesday, Health Minister Ong Ye Kung revealed that the mpox vaccine JYNNEOS will be offered to two key groups: healthcare workers at high risk of exposure and close contacts of confirmed cases.

The announcement comes as the World Health Organization (WHO) declared mpox a global public health emergency for the second time in two years due to the resurgence of clade 1 cases in Africa.

Minister Ong emphasized that while there is limited data on the virus, the government has sufficient information to implement precautionary measures. “We do not have full information on the characteristics of this virus, but we have good information on how it behaves,” he said. Ong added that Singapore’s response plan would remain flexible and adapt as the global understanding of the virus evolves.

Response Measures and Border Controls

As part of a whole-of-government approach, the Ministry of Health (MOH) has coordinated a comprehensive public health strategy to prevent the spread of mpox clade 1 in Singapore.

While no direct flights connect Singapore to countries experiencing mpox outbreaks, temperature and visual screening measures have been put in place at Changi and Seletar airports for travellers and crew arriving from affected regions. Screening at sea checkpoints has also been implemented for ships from mpox-affected areas.

Travellers are required to report any mpox-related symptoms (such as fever or rash) and provide travel history via the SG Arrival Card. Those displaying symptoms will be assessed by medical professionals at the borders and referred to hospitals if necessary.

Vaccination Strategy and Quarantine

The JYNNEOS vaccine, previously approved in Singapore for both smallpox and mpox, will be offered to two key groups. Healthcare workers at the National Centre for Infectious Diseases (NCID) and other high-risk facilities will be provided with pre-exposure prophylaxis, in addition to existing infection control protocols. Close contacts of confirmed mpox cases will receive a single vaccine dose within 14 days of exposure during their 21-day quarantine period. The MOH has assured that the current vaccine supply is sufficient to meet the needs of these priority groups.

MOH highlighted that a “significant” portion of the population—those born before 1981—may already have some immunity due to mandatory smallpox vaccinations administered in Singapore until that year.

Detection, Isolation, and Treatment

MOH has instructed all healthcare providers to be vigilant and promptly report any suspected mpox cases, especially those involving clade 1.

Suspected cases will be referred to designated hospitals for further assessment and testing, with paediatric cases directed to KK Women’s and Children’s Hospital and adult-child family groups to National University Hospital. Confirmed clade 1 cases will be isolated in healthcare facilities until they are no longer infectious to prevent further community spread.

Testing for mpox involves polymerase chain reaction (PCR) testing conducted at the National Public Health Laboratory. While there are no rapid point-of-care test kits available, cases are managed through supportive care. For severe cases, antivirals such as Tecovirimat may be used, aligning with treatment protocols in other countries.

Community Measures and Mask-Wearing

Based on current data, the virus spreads mainly through close physical contact, such as within households. Therefore, mask-wearing for the general public is not recommended unless there is significant evidence of respiratory transmission. MOH has stated that if respiratory spread becomes a concern, measures such as mask-wearing on public transport or in crowded indoor spaces may be considered.

In settings such as preschools and schools, existing infectious disease protocols—such as visual screenings for symptoms and hygiene measures—will continue to be implemented to control any potential spread. Additionally, MOH, in collaboration with the Ministry of Manpower and the National Environment Agency, has begun wastewater testing at migrant worker dormitories and the Onboard Centre to detect any presence of mpox.

Ongoing Surveillance and Preparedness

MOH will continue to work closely with international counterparts to monitor the evolving mpox situation. Border measures, detection protocols, and vaccination strategies will be adjusted as needed to safeguard Singapore’s public health.

As of now, Singapore has not detected any clade 1 cases, with all 14 mpox cases this year involving the less severe clade 2 subtype. However, Minister Ong stressed the importance of vigilance, particularly in protecting vulnerable groups such as children and the immunocompromised, should clade 1 reach Singapore.

“Our best course of action is to suppress the spread, provide proper treatment, and have an effective vaccination strategy in place,” Ong said. Despite the concern surrounding mpox, Ong reassured the public that it is unlikely to cause the level of disruption seen during COVID-19.

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Baby born with 26 fingers and toes in India, considered reincarnation of Hindu deity

A baby in Bharatpur, India, was born with 26 fingers and toes, believed to be a reincarnation of a Hindu deity.

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A baby was born with an astonishing 26 fingers and toes in a hospital in Bharatpur, a city in the northern Indian state of Rajasthan.

While medical experts describe the condition as a genetic anomaly known as polydactyly, the baby’s family is rejoicing, believing that their child is the reincarnation of a revered Hindu deity.

The baby, whose name has not been disclosed, entered the world with 14 fingers on its hands and 12 toes on its feet, leaving medical professionals both astounded and intrigued.

As reported by the Daily Mail on Tuesday (19 Sep), doctors described it as a genetic anomaly known as polydactyly, where someone is born with one or more extra fingers or toes. It can occur on one or both hands or feet.

However, the family is reported to be happy and openly refers to it as a reincarnation of Dholagarh Devi, a famous local deity whose temple is located near the girl’s birthplace. The deity’s statue depicts a young girl with multiple hands.

The baby’s mother, Sarju Devi, aged 25, expressed immense joy at the birth of her child. Sarju Devi’s brother, whose name was not disclosed, spoke to local media, proudly stating, “My sister has given birth to a baby with 26 fingers, and we consider it to be the incarnation of Dholagarh Devi. We are overjoyed.”

The baby’s father, Gopal Bhattacharya, a Central Reserve Police Force officer, is also reported to be ecstatic about the birth.

Dr BS Soni, a medical practitioner at the hospital where the baby was born, offered a medical perspective on the condition, saying, “Having 26 fingers is not harmful, but it is a genetic abnormality. The little girl is perfectly healthy.”

The big question now is whether the family from Bharatpur, in the northern Indian state of Rajasthan, plans to undergo surgery to reduce the number of fingers and toes on their newborn baby.

This decision is yet to be disclosed as the family continues to bask in the belief that their child is a divine reincarnation.

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