Connect with us

International

Google AI tool predicts danger of genetic mutations

Researchers at Google DeepMind have developed AlphaMissense, a tool predicting harmful genetic mutations, aiding rare disease research. It predicts 89% of mutations with 90% accuracy, advancing AI’s impact in natural sciences.

Published

on

WASHINGTON, UNITED STATES — Researchers at Google DeepMind, the tech giant’s artificial intelligence arm, on Tuesday introduced a tool that predicts whether genetic mutations are likely to cause harm, a breakthrough that could help research into rare diseases.

The findings are “another step in recognising the impact that AI is having in the natural sciences,” said Pushmeet Kohli, vice president for research at Google DeepMind.

The tool focuses on so-called “missense” mutations, where a single letter of the genetic code is affected.

A typical human has 9,000 such mutations throughout their genome; they can be harmless or cause diseases such as cystic fibrosis or cancer, or damage brain development.

To date, four million of these mutations have been observed in humans, but only two percent of them have been classified, either as disease-causing or benign.

In all, there are 71 million such possible mutations. The Google DeepMind tool, called AlphaMissense, reviewed these mutations and was able to predict 89 percent of them, with 90 percent accuracy.

A score was assigned to each mutation, indicating the risk of it causing disease (otherwise referred to as pathogenic).

The result: 57 percent were classified as probably benign, and 32 percent as probably pathogenic — the remainder being uncertain.

The database was made public and available to scientists, and an accompanying study was published on Tuesday in the journal Science.

AlphaMissense demonstrates “superior performance” than previously available tools, wrote experts Joseph Marsh and Sarah Teichmann in an article also published in Science.

“We should emphasize that the predictions were never really trained or never really intended to be used for clinical diagnosis alone,” said Jun Cheng of Google DeepMind.

“However, we do think that our predictions can potentially be helpful to increase the diagnosed rate of rare disease, and also potentially to help us find new disease-causing genes,” Cheng added.

Indirectly, this could lead to the development of new treatments, the researchers said.

The tool was trained on the DNA of humans and closely-related primates, enabling it to recognize which genetic mutations are widespread.

Cheng said the training allowed the tool to input “millions of protein sequences and learns what a regular protein sequence looks like.”

It then could identify a mutation and its potential for harm.

Cheng compared the process to learning a language.

“If we substitute a word from an English sentence, a person that is familiar with English can immediately see whether this word substitution will change the meaning of the sentence or not.”

— AFP

Continue Reading
Click to comment
Subscribe
Notify of
0 Comments
Newest
Oldest Most Voted
Inline Feedbacks
View all comments

International

Explosions on Hezbollah pagers in Lebanon leave nine dead and thousands injured

A series of explosions targeting Hezbollah members’ pagers in Lebanon killed at least nine people and wounded 2,750 others. Hezbollah blamed Israel for the sophisticated attack, which escalated ongoing tensions between the two, amid ongoing cross-border conflict.

Published

on

By

Explosions on Hezbollah pagers in Lebanon leave nine dead and thousands injured

Explosions targeting pagers used by Hezbollah members in Lebanon on Tuesday (17 Sept), resulted in at least nine deaths, including an 8-year-old girl, and approximately 2,750 injuries, with 200 being critical.

Most injuries were to the face, hands, or abdomen.

It is reported that eight of the deceased were Hezbollah members.

The group confirmed that at least two of its members were killed, one of whom was the son of a Hezbollah parliament member.

Hezbollah later announced that six additional members had died, though specific details were not provided.

The explosions occurred across multiple regions in Lebanon and affected several Hezbollah members.

Iranian Ambassador to Lebanon, Mojtaba Amani, was among those injured but sustained only minor injuries and remains under observation in a Beirut hospital.

Hezbollah and the Lebanese government have accused Israel of orchestrating a sophisticated remote attack.

According to an American official, Israel informed the United States that the operation involved detonating small amounts of explosives concealed within the pagers.

The Israeli military has declined to comment on the attack.

Tensions between Israel and Hezbollah have been high, particularly following the 7 October attack by Hamas that intensified the Gaza conflict.

The pagers involved were reportedly procured by Hezbollah following a February directive from its leader to stop using cellphones, which are more easily tracked by Israeli intelligence.

The pagers were acquired from Taiwanese company Gold Apollo but were tampered with before arriving in Lebanon.

Gold Apollo confirmed that its AR-924 pagers were used but stated they were produced and sold by a company called BAC.

The explosive material, embedded next to the battery in each pager, was triggered remotely by a message that appeared to come from Hezbollah’s leadership.

The pagers were programmed to beep for several seconds before detonating.

Hezbollah has accused Israel of carrying out this attack and promised retaliation.

Lebanese Information Minister Ziad Makary condemned the explosions as an “Israeli aggression.”

Hezbollah warned that Israel would face “just punishment” for the attack.

“We hold the Israeli enemy fully responsible for this criminal aggression that also targeted civilians,” Hezbollah said.

Independent cybersecurity experts have indicated that the explosions were caused by small explosive charges implanted in the pagers.

Mikko Hypponen of WithSecure noted that the size and strength of the explosions suggested modifications to the devices.

“These pagers were likely modified in some way to cause these types of explosions — the size and strength of the explosion indicates it was not just the battery.”

Israeli cybersecurity analyst Keren Elazari described the attack as targeting Hezbollah’s vulnerabilities.

The pager bombings are likely to heighten Hezbollah’s concerns about security and communications as the conflict with Israel continues.

“This attack hit them in their Achilles’ heel because they took out a central means of communication,” Ms Elazari said.

“We have seen these types of devices, pagers, targeted before but not in an attack this sophisticated.”

The ongoing exchanges of fire between Israel and Hezbollah have resulted in numerous casualties and displacement on both sides.

Jeanine Hennis-Plasschaert, the UN Special Coordinator for Lebanon, condemned the attack and expressed concern about the escalating violence in an already volatile situation.

Continue Reading

International

Attack on Hezbollah pagers injures hundreds across Lebanon, including Iran’s ambassador

Hundreds were injured in explosions across Lebanon on 17 September, targeting pagers used by Hezbollah members. Iran’s ambassador to Lebanon, Mojtaba Amani, was among the wounded.

Published

on

Hundreds of people were injured on 17 September 2024, in an attack targeting pagers used by Hezbollah members in Lebanon.

The explosions affected multiple regions, with dozens of Hezbollah members reportedly wounded.

Iranian Ambassador to Lebanon, Mojtaba Amani, was among those injured, according to Iranian state media, suffering a superficial injury. He remains under observation in a Beirut hospital, per IRNA.

The Lebanese Ministry of Health has issued urgent warnings to citizens to discard pager devices and instructed hospitals to be on “high alert.”

The ministry also called for blood donations due to the large number of casualties being transferred to hospitals. The explosions primarily impacted Hezbollah strongholds, including the southern suburbs of Beirut and the Beqaa valley towns of Ali Al-Nahri and Riyaq.

The blasts are believed to be the result of “hacked” pager devices, according to Lebanon’s Internal Security Forces and the state media outlet NNA.

In addition to Ambassador Amani, two Iranian embassy employees were injured, as reported by Iran’s semi-official Fars news agency.

Footage from CCTV and social media showed the severity of the blasts. In one clip, a man in a supermarket was caught in an explosion, dropping to the ground in pain. Other videos from Lebanese hospitals depicted the overwhelming number of injured, including children with facial and hand injuries.

The Israeli military, which has engaged in conflict with Hezbollah amid the ongoing Gaza war since October 2023, declined to comment on the incident.

Continue Reading

Trending